Monocytes and neutrophils are the most abundant white cells in peripheral blood and essential components of the innate immune system, which comprises the first line of defense against infection. Although both are derived from the myelomonocytic progenitor cell and have similar functions as phagocytes and cytokine producing cells, monocyte are immature cells that have additional functions in antigen presenting and the capacity to further differentiate into macrophages.
The seventh Blueprint data release is now available. Within Blueprint we have so far isolated cells from 79 Bone marrow, 217 Venous blood, 111 Cord blood, 10 Tonsil, 8 Thymus and 7 Cell line samples and performed epigenomic analysis including RNA-seq, DNAme-seq, DNAseI-seq and 8 different ChIP-seq experiments. All the sequence data from Blueprint were remapped to new human genome assembly GRCh38 for this release.
This includes data from monocytes, granulocyte neutrophils, eosinophils, macrophages ( M0 , M1 and M2 ), naive CD4+ and naive CD8+ cells and cell line samples.
Future releases of data for additional samples are planned at a regular basis.