Monocytes and neutrophils are the most abundant white cells in peripheral blood and essential components of the innate immune system, which comprises the first line of defense against infection. Although both are derived from the myelomonocytic progenitor cell and have similar functions as phagocytes and cytokine producing cells, monocyte are immature cells that have additional functions in antigen presenting and the capacity to further differentiate into macrophages.
Within Blueprint we isolated cells from 7 adult blood and 4 cord blood samples and performed a full epigenomic analysis including RNA-seq, DNAme-seq, ChIP-seq for 6 histone modifications and DNAseI-seq.
Today the data for 8 monocyte samples and 7 neutrophil samples are released.
Future releases of data for additional samples are planned at a regular basis.
Information about the reuse of data generated by the EC funded FP7 High Impact Project, Blueprint can be found via the following link.
Information about data access for non-BLUEPRINT members can be found via the following link.