Publications
Below you will find links to the publications of 2016 which describe research financed by the BLUEPRINT project. For the publications of the previous years, please use the links on the left.
| Genome Medicine November 2016 | Genome Biology December 2016 | Clinical Epigenetics December 2016 |
| Making sense of big data in health research: towards an EU action plan. | Integrating epigenomic data and 3D genomic structure with a new measure of chromatin… | Sirtuin functions and modulation: from chemistry to the clinic. |
| Nature Rev. Genet November 2016 | Scientific Reports November 2016 | Nature Communications November 2016 |
| From profiles to function in epigenomics. | Changes of bivalent chromatin coincide with increased expression of developmental... | Increased DNA methylation variability in type 1 diabetes across three... |
| Cell November 2016 | Cell November 2016 | Cell Metabolism November 2016 |
| The International Human Epigenome Consortium: a Blueprint for scientific… | A cornucopia of advances in human epigenomics | Glutaminolysis and fumarate accumulation integrate immunometabolic and … |
| Cell November 2016 | Cell November 2016 | Cell November 2016 |
| Genetic drivers of epigenetic and transcriptional variation in human immune cells | Lineage-specific genome architecture links disease variants to target genes | Beta-glucan reverses the epigenetic state of LPS induced immunological ... |
| Immunity November 2016 | Cell Stem Cell November 2016 | Cell November 2016 |
| Transcriptional landscape of human tissue lymphocytes unveils … | DNA methylation dynamics of human hematopoietic stem cell differentiation | The allelic landscape of human blood cell trait variation and links to common complex… |
| Cell Reports November 2016 | Cancer Cell November 2016 | Cell Systems November 2016 |
| Distinct trends of DNA methylation patterning in the innate and adaptive… | Decoding the DNA methylome of mantle cell lymphoma in the light of… | The BLUEPRINT data analysis portal |
| Cell Reports November 2016 | Cell Reports November 2016 | Cell Reports November 2016 |
| eFORGE: a tool for identifying cell type-specific signal in epigenomic data | CD8+ T cells from human neonates are biased towards an innate immune response | The hematopoietic transcription factor RUNX1 and ERG prevent AML1-ETO… |
| Nature Biotechnology September 2016 | Epigenetics October 2016 | Pediatr. Blood Cancer October 2016 |
| Co-ChIP enables genome- wide mapping fo histone mark co-occurrence at … | Identification and character- ization of PKF118-310 as a KDM4A inhibitor | DNA methylation profiling of pediatric B-cell lymphoblastic leukemia with KMT2A … |
| Cell Augustus 2016 | Cancer Research August 2016 | Science Advances September 2016 |
| The spectrum and regulatory landscape of intestinal innate lymphoid cells are … | CNS1 somatic mutations in penile squamous carcinoma. | Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structiral … |
| Clinical Cancer Research June 2016 | Science July 2016 | Nucleic Acids Research July 2016 |
| c-Myc modulation & acetylation is a key HDAC inhibitor target in cancer | Early life nutrition modulates the epigenetic state of specific rDNA genetic … | DeepBlue epigenomic data server: programmatic data retrieval and analysis of … |
| Nature Communications June 2016 | Nature Communications June 2016 | Nature Biotechnology June 2016 |
| Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype... | Information recovery from low coverage whole-genome bisulfite sequencing | Saturation analysis for whole- genome bisulfite sequencing data |
| Nucleic Acids Research May 2016 | Blood June 2016 | Nature Biotechnology June 2016 |
| Dynamic recruitment of Ets1 to both nucleosome-occupied and – depleted enhancer ... | A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, …. | Quantitative comparison of DNA methylation assays for biomarker development and ... |
| Epigenetics Chromatin March 2016 | Nature Commun. April 2016 | Genome Biology April 2016 |
| Tissue-independent and tissue-specific patterns of DNA methylation … | Large-scale production of megakaryocytes from human pluripotent stem … | Single-cell epigenomics: powerful new methods for understanding gene … |
| Oncotarget March 2016 | Nature Genetics March 2016 | PloS Genetics March 2016 |
| Histone acetyltransferase inihibitor CPTH6 preferentially targets lung cancer… | DNA methyaltion dynamics during B cell maturation underlie a continuum of … | Quantitative trait loci identify functional noncoding vairation in cancer. |
| J Med Chem February 2016 | Scientific Reports February 2016 | Bioinformatics February 2016 |
| 1,4-dihydropyridines active on the SIRT1/AMPK pathway ameliorate skin repair… | Significant impact of miRNA- target gene networks on genetics of human complex.. | LOLA: enrichment analysis for geneomics region sets and regulatory elements in … |
| Cell Reports February 2016 | Biochem Pharmacol February 2016 | J Med Chem February 2016 |
| Epigenomic co-localitation and co-evolution reveal a key role for 5hmC as a … | The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene … | Discovery of a novel inhibitor of histone lysine-specific … |
| Proteomics January 2016 | Autoimmunity January 2016 | Genome Research February 2016 |
| Secretome profiling of cytokines and growth factors reveals that neuro-glial … | Histone deacetylase inhibitors restore IL-10 expression in lipopoly… | Metilene: fast and sensitive calling of differentially methylated regions from ... |
| Database January 2016 | Genome Biol. January 2016 | Nature Communication January 2016 |
| Ensembl regulation resources | Epigenomic analysis detects aberrant super- enhancer DNA … | Non-CG DNA methylation is a biomarker for assessing endodermal… |
| Dev Cell January 2016 | Nucleic Acids Res. January 2016 | Stem Cell Int January 2016 |
| Maternal DNA methylation regulates early trophoblast development | Ensembl 2016 | Epigenetic control of haematopoietic stem cell aging and its clinical … |
| Nature Immunology January 2016 | Biochim Biophys Acta January 2016 | Cell Reports January 2016 |
| The role of the local environment and epigenetics in shaping macrophage … | D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts | Non-canonical PRC1.1 targets active genes independent of H3K27me3 and is ... |